Viagra’s (Sildenafil Citrate) advent and commercial availability was started in 1998, the market for the treatment of erectile dysfunction grown up drastically along with the increased level of sale of Viagra.
Some of the quick facts about Viagra are as follows:
Viagra is rapidly absorbed by mouth with a bio-availability of about 40% and peak concentrations of the chemical are in the blood within 30-120 minutes.
This has been one of the advantages for viagra, in that it is capable of being taken as a tablet and is relatively quick-acting. The affects of Viagra will last, on an average, for up to 4-hours.
Viagra’s affect is to inhibit an enzyme known as PDE5, which naturally occurs in erectile tissue.
PDE5 can break down cyclic GMP (cGMP acts as a second messenger much like cyclic AMP, most notably by activating intracellular protein kinases in response to the binding of membrane-impermeable peptide hormones to the external cell surface.), the substance that is produced during sexual arousal and causes vascular and muscular changes that eventual lead to an erection.
Some of the viagra side effects noticed like: disturbances, dizziness, and nasal congestion. Other rarer adverse effects reported include diarrhea, muscle pain, skin rashes, and urinary or respiratory-tract infection.
Viagra is well known to be contraindicated with organic nitrates. These are drugs that are often used to treat heart conditions such as hypotensive conditions i.e. low blood pressure. Viagra appears to potentiate the effects of nitrates and therefore the two must not be taken concurrently.
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